This web page was produced as an assignment for Genetics 564 at UW-Madison in Spring 2014.
Research Tools
A great scientist needs great tools in his/her toolbox to conduct quality research. Here, three types of tools are briefly described. Click on any of the tools to learn more about genetic tools available for studying PEX1 and ZSS.
Mutant and RNAi Phenotypes
There are various, publicly available mutant and RNAi strains of PEX1 deficient organisms. For example, the small mouse depicted on the left is a PEX1 deficient model. These can be used to study the functions of PEX1, genetic interactions, and phenotypes associated with the related diseases of ZSS.
There are various, publicly available mutant and RNAi strains of PEX1 deficient organisms. For example, the small mouse depicted on the left is a PEX1 deficient model. These can be used to study the functions of PEX1, genetic interactions, and phenotypes associated with the related diseases of ZSS.
Small Molecules
Chemical genetic screens can be used to identify small molecules that affect the expression and function of a particular gene. While a full-scale chemical genetic screen has not been conducted for PEX1, other molecules have been identified that affect PEX1 function.
Chemical genetic screens can be used to identify small molecules that affect the expression and function of a particular gene. While a full-scale chemical genetic screen has not been conducted for PEX1, other molecules have been identified that affect PEX1 function.
Microarrays
Microarrays are often used to study transcriptome-wide changes in expression across systems under different conditions. Microarrays of PEX1 deficient animals has helped elucidate which processes are affected in these models.
Microarrays are often used to study transcriptome-wide changes in expression across systems under different conditions. Microarrays of PEX1 deficient animals has helped elucidate which processes are affected in these models.
Banner image retrieved from: <http://www.iatsmartdial.com/2013/10/25/compliant-dialing-its-in-our-dna-how-about-yours>.
Image References
mice: http://www.sciencedirect.com/science/article/pii/S1096719214000341
molecule: http://www.rain.org/homeschool/chemistry/chemistry-intro-1.html
microarray: http://bio.cse.ohio-state.edu/MicroarrayDesigner/
Image References
mice: http://www.sciencedirect.com/science/article/pii/S1096719214000341
molecule: http://www.rain.org/homeschool/chemistry/chemistry-intro-1.html
microarray: http://bio.cse.ohio-state.edu/MicroarrayDesigner/