CLUSTAL O(1.2.0) multiple sequence alignment Caenorhabditis_elegans -----------MNQSYPAFVSFHSLSNCFAYAKLLTAINNANDLSSANEKFGGPLLGNFR Saccharomyces_cerevisiae MTTTKRLKF-----ENLRIQFSNAIVGNFLRLPHS--I--INVLESTNYAIQEFGIAV-H Drosophila_melanogaster ------------MFKRTFKVVYRPIRSNFVLLPDQ--Y--YGVVSTYDTGCLSLQYNG-- Arabidopsis_thaliana MSRNRQIIIPDDVMETEAVVNTVAGVDCFVSLPRQ--L--LHALQSTSSSPLPPLLPV-E Danio_rerio ------MLG--SQGIQPVTLVFNNSKNCFLHLSSN--F--ATHLCLHENQILELSWGV-- Mus_musculus MWSSDRLAG-AGSGGAVVTVAFTNARDCFLHLPRR--L--VAQLHLLQNQAIEVASDH-- Rattus_norvegicus MWSSDRLAG-AGSGGAVVTVAFTNARDCFLHLPRH--L--VAQLHLLQNQAIEVTGDH-- Homo_sapiens MWGSDRLAG-AGGGGAAVTVAFTNARDCFLHLPRR--L--VAQLHLLQNQAIEVVWSH-- Bos_taurus MWGSGRLAG-SGG-GAAVTVAFTNARDCFLHLPRR--L--VAQLHLLQNQAIEVAWGH-- * : . Caenorhabditis_elegans MKSCDNPN---IYCDIQVFGQFPFTNVFINSVFAEVSGFHEKQ---EVILEKMESKTYCS Saccharomyces_cerevisiae SHNSDIPIVHLGWDGH--DSGSSENVVLINPVLATVYDLNQKSPLVDLYIQRYDHTHLAT Drosophila_melanogaster ------RTHYASWAPQKGGGGIKDTEIGINARAAKEIGLHEND---LVKCALIADVLNLR Arabidopsis_thaliana -----LRSGDRRWSVAWSGSSSSSSAIEIARVFAESISLPDGT---VVKVRVLPNVPKAT Danio_rerio -----SAPVFLSWIRSRSS--GPEDRVEISRQLGEKLGLRDGE---QGYLRPCLQVQSVQ Mus_musculus ------QPTYLSWVEGRHFNDQSENVAEINRQVGQKLGLSSGD---QVFLRPCSHVVSCQ Rattus_norvegicus ------QPTYLSWVEGRHFNDQSENVAEINRQVGQKLGLSSGD---QVFLRPCSHVVSCQ Homo_sapiens ------QPAFLSWVEGRHFSDQGENVAEINRQVGQKLGLSNGG---QVFLKPCSHVVSCQ Bos_taurus ------QPAFLSWVEGRHFSDEGENVAEINRQVGQKLGLSNGA---QVFLKPCSHVVSCQ : * . : . Caenorhabditis_elegans HIEVAPRTEDDYSVIAQSQSSI-ENEFLNQIRLVSQNMIIPHFLSPGVYVQFRILNIVPA Saccharomyces_cerevisiae EVYVTPETSDDWEIIDANAMRFQNGEILHQTRIVTPGETLICYLEG-IVTKFKIDRVEPS Drosophila_melanogaster SVHVTPVSSKDWEIIELSTEKI-SGSVLEQTRIVNSTQILIVWINKSMQVALTVDRLKPH Arabidopsis_thaliana LVTVEPETEDDWEVLELNAELA-EAAILSQVRILHETMKFPLWLHDRTVIRFSVVSTFPS Danio_rerio QVSVEPLSPDDWEILELHSLAL-EQRILDQIRVVFSDGVFPVWVDQHTVIYIRIASLTPS Mus_musculus QVEVEPLSADDWEILELHAISL-EQHLLDQIRIVFPKAVVPIWVDQQTYIFIQIVTLMPA Rattus_norvegicus QVEVEPLSADDWEILELHAISL-EEHLLDQIRIVFPKAIVPIWVDQQTYIFIQIVALMPT Homo_sapiens QVEVEPLSADDWEILELHAVSL-EQHLLDQIRIVFPKAIFPVWVDQQTYIFIQIVALIPA Bos_taurus QVEVEPLSADDWEILELHAASL-EQHLLDQIRIVFPKAIFPVWVDQQTYIFIQIAALIPD : * * : .*:.:: . .* * *:: . :: : : * Caenorhabditis_elegans SNKPVMLNNDTELHVQTVTEGS-Q------NDEKAT-----MAQKV-SNIVQDLSMQGFL Saccharomyces_cerevisiae MKSAR-ITDGSLVVVAPKVNKTRLVKAEYGHSNK------TILKNGAIQLLKKVILR--- Drosophila_melanogaster MNYGR-IDHNTELVVAPNLYKGLTNGTSNGVIEENT--KLSRSKTT-AQVKDELTEK-L- Arabidopsis_thaliana KGVVQ-LVPGTEVAVAPKRRDRNLKAKKSQEKECNNVKALLRVQETDRSAFHEADVKGFE Danio_rerio VPYGR-LEQFTELIVSPKLHPGSELLHKPQSEEPRQHQNVNITSSS---ISN-------- Mus_musculus APYGR-LETNTKLLIQPKTRQAKESTFPKEGDAHGQVHSYGREQKG---LSKELQTRQLH Rattus_norvegicus APYGR-LETNTKLLIQPKTRQAKESTFPKEGDARGQAHNYGREQKG---TVKELQTKQLH Homo_sapiens ASYGR-LETDTKLLIQPKTRRAKENTFSKADAEYKKLHSYGRDQKG---MMKELQTKQLQ Bos_taurus APYGR-LETDSRLLIQPKTRQAKESTFSEAEDIPGKFHHYGRDQKG---LTKELQTKQLQ : : : : . . Caenorhabditis_elegans SNYVINLEKTPIIGRVLPKK---TVELWVKSGL-------EKLDKSTIYIPGKESCLYSE Saccharomyces_cerevisiae ---------STVCKMDFPKDNLFV----VYISDGAQLPSQKGYASIVKCSLRQSKKSDSD Drosophila_melanogaster ----------------TPLTHSST------VSN------VK-------NTIQRNKRQDHM Arabidopsis_thaliana LR-VALTS-IAYIHPETAKKHSLESLQ--LI----------SVSPRI-PLKGSAKKDE-A Danio_rerio ----------ASQDSQNDHPESLNEGHWGGIAD------LKGLVRYL-FTRGREPAKEKI Mus_musculus TNSEGITA-SNGRDPKVPGG-PLKPSWWAVLG-------------SM-LSFGPDSKQESA Rattus_norvegicus KNTEAVPV-SNGRNPEVPGD-SVKPRWWAVLG-------------SM-FSFGPDNKQESA Homo_sapiens SNTVGITE-SNENESEIPVDSSSVASLWTMIG-------------SI-FSFQSEKKQETS Bos_taurus SNTVGVAG-SKERESEGRIDSSFIPSLWTMIG-------------SI-FSSGSEKKRDTS Caenorhabditis_elegans HGIVEIRSQG-------RGENEERFQFFYLHR-------------------SPNIYLRNQ Saccharomyces_cerevisiae N--------------KSVGIPSKKIGVFIKCDSQIPEN-----------HIALSSHLWDA Drosophila_melanogaster ERL------KK-----DLRRESSRSFEFRVIR---------------------G--LWRE Arabidopsis_thaliana LNMKNSEASKVAENGTSSAKKEPRQAILRLVFSDLAAKGHLMMVESLRLYLGAGLHSWVY Danio_rerio ---------A-----VPTIPAILKDCILRTCGSPPRSVSHH-----GSCHGDVHILPWNL Mus_musculus WGSLELGAFK-----NMQSQAAPLEGTFRVCQVQPPSARTTTATSVFHKHCTAHVFPWDQ Rattus_norvegicus WGSLELGAFK-----NMQSQTVPLDSIFRVCQVQPPSVHNTPANSVFHKHCTVHVFPWDQ Homo_sapiens WGLTEINAFK-----NMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWDQ Bos_taurus WGLTEVNAFK-----NMQSAVVPLDNIFRVCKSQPPSMCKASATSVFHKHYAIHVFPWDQ : Caenorhabditis_elegans S----NE-LDASLSHMFESLQLENRCHCVEGTNTLEPYMNIKIFGVTQN----------R Saccharomyces_cerevisiae F--FTHPMNGAKIKLEFLQMNQA-N-----IISGRNATVNIKYFGKD------------- Drosophila_melanogaster QAQESDVFVNGKHLPEFFDLDLF-Y--CMHTAADKDYYVRVRTVEDDIEDDLPE------ Arabidopsis_thaliana L--RGCNVNEDKEIP-----ALS-LSPCVFKISENE-----KVLDKGTD-RLGNN---NS Danio_rerio Q--EQENWNPGQSALTYGRLSKI-LSPKELREKVKQ-----AMEKKKIR----DAS---H Mus_musculus E--YFDV--EPSFTVTYGKLVKL-HSPKQQQDKSKQ-----GVLLPDKEKQLSKSPDHKQ Rattus_norvegicus E--YFDV--EPSFTVVYGKLVKL-HSPKQQQDKSKQ-----GVLLPEKEKQLSQSPGHKR Homo_sapiens E--YFDV--EPSFTVTYGKLVKL-LSPKQQQSKTKQ-----NVLSPEKEKQMSEPLDQKK Bos_taurus E--YFDV--EPSFTVTYGKLVKL-LSPKQQQSRTKQ-----NVLSPEKEKQMSEPLDQKQ . : Caenorhabditis_elegans IC-------TLRYCEIMMEKETFQWV--------------KEFELTNVLTKSLHSELQGN Saccharomyces_cerevisiae -----VPTKS-----------------------------------GDQYSKLLGGSLLTN Drosophila_melanogaster ---TIHPSIELNANLM-----KL--------------LGIKELERVVLRPKTTVVNFVEK Arabidopsis_thaliana VRKSSHPPSGLSTYVD-----VVDWSVHDKVVTALSSEGLHDEGNHDKNKK--GLEYLTR Danio_rerio KE-KDTEEHMENSAVV-----RMLCH------------NINRLQEDQKLN-KCEEIYSGK Mus_musculus IS-SNRSEEAAEACVL-----KVVWN------------GLEELKNATEFTESLELLHRGK Rattus_norvegicus IG-SDGSEEAAETCVL-----KVVWN------------GLEELKNATEFTKSLEPLHHGK Homo_sapiens IR-SDHNEEDEKACVL-----QVVWN------------GLEELNNAIKYTKNVEVLHLGK Bos_taurus VS-PDHSHKAGKACVL-----KVVWN------------GLEELKNAIKYTKNLDVLHLGK . Caenorhabditis_elegans PILLSVEGKELDVAVDDKAIRLKVVPSMKGLVKR--------------V----------- Saccharomyces_cerevisiae NLILPTEQIIIEI---------K---------KG--------ESEQQLCNLNEISNESVQ Drosophila_melanogaster IELFANKKTHYKI----------------------------------------MENAFKR Arabidopsis_thaliana LWSLAQLDAMASV---------TGVDVSSLIVGRETFFHFEVRGLESYKSIDGQPSVNDR Danio_rerio IWIPKMLQRRLKIDLH-SAVRIQPLKSMPRLAET--VMVQPLQPLAESEKEEDIQMAFLN Mus_musculus VWP-------------------------------------------KDVNEETIKTVFSS Rattus_norvegicus VWIPADLRKRLNIEMH-AVVRITPLETTPVIPRA--LRLQPAENLPRDVSEEEVKAVFSS Homo_sapiens VWIPDDLRKRLNIEMH-AVVRITPVEVTPKIPRS--LKLQPRENLPKDISEEDIKTVFYS Bos_taurus VWIPHDLRKRLNIEMH-AVVRITPVEITPNIPRS--LKLQPTENLSEDVSEEDIKTVFYS Caenorhabditis_elegans ------TE-NTC-------F----------------------------------LFDLTT Saccharomyces_cerevisiae WKVTQ--------MGKEEVK------DIIERHLPKHYHVK-------------------- Drosophila_melanogaster F-VIERTQHKPMLFNQEEVVRLEDDLLVTVGILPEHFRYCVVDA----------QFLKES Arabidopsis_thaliana WESGKKDKHTPLEILYVMTVS--DESLLGDKF--AGYDLSLDRSEK-----SDNVVHIEP Danio_rerio WFDAQSHQPLTCLTGRSNII----LLPCAEGK--EEFALTVLKPEQ---QQEDELFFLSN Mus_musculus WVQQSATTMLPLVISKEERI----KLEIKDGL--REFSLSTVHSQEKEKEEGKTVFVLSS Rattus_norvegicus WLQESATTMFPLIISKQECI----KLEIKDGL--KEFSLSIVHSQEKEKEQGRTVFVLSP Homo_sapiens WLQQSTTTMLPLVISEEEFI----KLETKDGL--KEFSLSIVHSWEKEKD--KNIFLLSP Bos_taurus WLQQSATTAVPLIVSEEEYI----KLEMKDGV--KEFSLNIVHSWEKEKE--ENIFLLST Caenorhabditis_elegans E----LIFQQLGDLKQKHGDTENTRRRRKRTEEAEASEQIP--QKPETSTM---ENFGFA Saccharomyces_cerevisiae ---------ETGE-------V-----SRTSKDE---DDFIT------------VNSIKKE Drosophila_melanogaster KIYAADLVRPVGE--------IIKEETPP--------TSPL--SVQDLIQLPEYDKIVDQ Arabidopsis_thaliana V-LEKMNL---GE-------PIYLKSAK--------ETHCNKGVSPDISSLTWMGPIVSD Danio_rerio SLLRKTDIQIARE-------PHNSDHRGSDNDT---EDQCL--GFPSLSSLGGVEDISRS Mus_musculus ILLQKISVQVLLE-------PMIKEEQS---AE---IDFLL--PSLTLSSLGGVSALGAS Rattus_norvegicus ILLQKISVQVLLE-------PMIGE-HS---EE---IDILL--PSLTLSSLGGVSSLSVS Homo_sapiens NLLQKTTIQVLLD-------PMVKEENS---EE---IDFIL--PFLKLSSLGGVNSLGVS Bos_taurus NLLQKMTIQVLLD-------PMVKEENS---EE---IDFIL--PFLKLNCLGGVNSLGVS : : Caenorhabditis_elegans ---QNKHFVQIGSHSKLLSELDKVCCGGKQHVMVLGGNGSGKTTFIKKLARRLSH-NSSV Saccharomyces_cerevisiae MV-----NYL----------T--SPIIATPAIILDGKQGIGKTRLLKELIN--EVEKDHH Drosophila_melanogaster VVQELRMNL-------CLSAD--NSVMRQCNVLLAGASGTGKTVLVERILDQLSR-KPDY Arabidopsis_thaliana VIKRM--TVLLSPAAGMWFSK--FKIPSPGHILIYGPPGSGKTILARAAAKYFEEQKDLL Danio_rerio AFQHISHALLGGSLSRELIST--GRGLRGGALLITGAKGSGKSSLSRALCR--KASEDLD Mus_musculus AMEHITHSLLGRPLSRQLMAL--VAGLRNGALLITGGKGSGKSTFAKAICK--EAQDTLD Rattus_norvegicus AMEHITHSLLGRPLSRQLMAL--VAGLRNGALLITGGKGSGKSTLAKAICK--EAHDALD Homo_sapiens SLEHITHSLLGRPLSRQLMSL--VAGLRNGALLLTGGKGSGKSTLAKAICK--EAFDKLD Bos_taurus SMEHITHSLLGRPLSRQLVSL--VAGLRNGALLLTGGKGSGKSTLAKAICK--EAFDILD ::: * * **: : . . . Caenorhabditis_elegans TFCKMVPCALLKGR-SADIIEKLLSDTLHEMEVKKPSCLFLDDFDVILPQIDQEQRHLAM Saccharomyces_cerevisiae IFVKYADCETLHETSNLDKTQKLIMEWCSFCYWYGPSLIVLDNVEALFGKPQANDGDPSN Drosophila_melanogaster CHFEFFHGSRSKGR-KTESIQKDLRNIFTSCLQHAPAIVVLENLDVLAHAAGEQSSQDG- Arabidopsis_thaliana AHVILVSCSTLALE-KVQHIHHVLSSVIAEGLEHAPSVIILDDLDSIISSSSDTEGTQA- Danio_rerio AHIQLLDCKTLKGK-RTDTIRQRLEDVFEQAVWRQPSVVLLDDLDHVAGAATSPEHEHGP Mus_musculus ARVETVDCKALRGK-RLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSVPEQEHSP Rattus_norvegicus AHVEMVDCKALRGK-RLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSTPEHEHSP Homo_sapiens AHVERVDCKALRGK-RLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSP Bos_taurus AHVEIIDCKALRGK-RLENIQKTLAAAFSEALWRQPSVVLLDDLDLVVGRSALPEHEHSP : .: : *: :.*::.: : . . Caenorhabditis_elegans EKVV---------------SVFAQKLR----TTEVSVVLVAQRLSSLNDGFVEQVMRARP Saccharomyces_cerevisiae NGQWDNASKLLNFFINQVTKIFNKD------NKRIRVLFSGKQKTQINPLLFD-----KH Drosophila_melanogaster --EY---YNRMADTVYQLIVQYTT-------NNAIAVIATVNELQTLNKRLSS--PRGRH Arabidopsis_thaliana -SVG---VTMLTKFLTDVIDDYGEYRNSSCGIGPLAFVASVQSLEQIPQ-TLS--S--SG Danio_rerio EAVL---RQHISQSLKDLVDEIVLRSS------LIALIVTAQTEHALHPTLTV--VQGSH Mus_musculus EAVQ---SQRLAHALNDMIKEFVSTGS------LVALIATSQLQQSLHPSLVS--AQGIH Rattus_norvegicus EAVQ---SQRLAHALNNMIKEFVSMGS------LVALIATSQLQHSLHPSLVS--AQGVH Homo_sapiens DAVQ---SQRLAHALNDMIKEFISMGS------LVALIATSQSQQSLHPLLVS--AQGVH Bos_taurus EAVQ---SQRLAHALNDLVKEFISMGS------LVALIATSQSQHSLHPLLVS--AQGIH : .: : : Caenorhabditis_elegans IVSRKIELEQLTKEDRCEIFETFLDLPE-------NSD-IISEIVKKSDGYTFSEIEKLA Saccharomyces_cerevisiae FVSETWSLRAPDKHARAKLLEYFFSKN---QIMKLNRDLQFSDLSLETEGFSPLDLEIFT Drosophila_melanogaster VFQTVARLPNLERADREIILRELC------SHINVAKDLDLVKFSNLTEGYRKCDLVQFV Arabidopsis_thaliana RFDFHVQLAAPATSERGAILKHEIQKRLLDCSED-----ILLNLAAKCEGYDAYDLEILV Danio_rerio FFQSFCKIPTPDQAQRVEILKSLIVK-KSFQ--VCQTTLDLDSVAKETEGFMARDLNLLL Mus_musculus TFQCVQHLQPPNPEQRCEILHSVVKN-KLGCDISNFPDLDLQCIAKDTEAFVARDFTVLV Rattus_norvegicus TFQCIQHIQPPDQEQRCEILHSVVKN-KLGCDISKSPDLDLKCIAKETEAFVARDFTVLV Homo_sapiens IFQCVQHIQPPNQEQRCEILCNVIKN-KLDCDINKFTDLDLQHVAKETGGFVARDFTVLV Bos_taurus IFQCVQHIQPPDQDQRCEILHAIIKN-KLDCDMKRFTGLDLQRIAKETEGFVARDFTMLV .. : * :: : . .: :: : Caenorhabditis_elegans VSINVECAIK--------GVKYITEIEVEKAFECFVAGKMGKIEDG--------QVLPTM Saccharomyces_cerevisiae EKIFYDLQLERD------CDNVVTRELFSKSLSAFTPSALRGVKL-----TK--ETNIKW Drosophila_melanogaster ERAIFYAYRISKTQ------PLLTNDQLIESLEHTNSYCLQGIQSNQRTGNDADANEMRV Arabidopsis_thaliana DRAVHAAIGRHLPLESNISKYNLVKEDFTRAMHDFVPVAMRDITK-----SASEGGRLGW Danio_rerio ERAIHANTLHNS--------EDLSCKDFRQALQGFTPPSLWDAQL-----QA--PSGAGM Mus_musculus DRAIHSSLSRQHSS--SREDLTLTTSDFQKALRGFLPASLRNVNL-----HK--PRDLGW Rattus_norvegicus DRAIHSSLSRQQNP--TREGLTLTTADFQKALRGFLPASLRNVNL-----HK--PRDLGW Homo_sapiens DRAIHSRLSRQSIS--TREKLVLTTLDFQKALRGFLPASLRSVNL-----HK--PRDLGW Bos_taurus DRAIHSHLSHQNVY--TREELVLTTLDFQKALRGFTPVSLRNVNL-----HK--PRDLGW : . .:: : Caenorhabditis_elegans EDVGGMFEQKKLLEQVIIWPRKYPQLFESVGVPVSKGILLHGPSGCGKTLLANATISNSN Saccharomyces_cerevisiae GDIGALANAKDVLLETLEWPTKYEPIFVNCPLRLRSGILLYGYPGCGKTLLASAVAQQCG Drosophila_melanogaster EELPGLESVVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGTGKTYLVSQLATSWN Arabidopsis_thaliana EDVGGVTDIKNAIKEMIELPSKFPKIFAKSPLRLRSNVLLYGPPGCGKTHIVGAAAAACS Danio_rerio ERIGGLHEARQLLMDIILLPAKYPLLFSSLPLRQCSGVLLYGAPGTGKTLLAGAVAKESG Mus_musculus DKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESG Rattus_norvegicus DKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESG Homo_sapiens DKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESR Bos_taurus DRIGGLHDVRQILVDTIQLPAKYPELFANLPIRQRTGVLLYGPPGTGKTLLAGVIAWESG : .: . : : : * :: :* : :**:* * *** :. Caenorhabditis_elegans FSVVNVKGPELLSKYIGASEENVRLVFEKARSCAPCILFFDELDSLAPKRGHDSTGVTDR Saccharomyces_cerevisiae LNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCILFFDEFDSIAPKRGHDSTGVTDR Drosophila_melanogaster LRIISVKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRGHDSTGVTDR Arabidopsis_thaliana LRFISVKGPELLNKYIGASEQAVRDIFSKAAAAAPCILFFDEFDSIAPKRGHDNTGVTDR Danio_rerio MNFISIKGPELLSKYIGASEQAVRDVFQRAQQAKPCILFFDEFDSLAPRRGHDNTGVTDR Mus_musculus MNFISIKGPELLSKYIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDR Rattus_norvegicus MNFISIQGPELLSKYIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDR Homo_sapiens MNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDR Bos_taurus MNFISVKGPELLSKYIGASEQAVRDVFVRAQAAKPCILFFDEFESIAPRRGHDNTGVTDR : .:.::***:* *:** **: :* :* :* **:*****::*:**:****.****** Caenorhabditis_elegans VVNQLLTELDGAEGGMKGVIILGCTSRIDLIDDALLRPGRFDHHVYCGHPEKTERLDIMK Saccharomyces_cerevisiae VVNQLLTQMDGAEG-LDGVYILAATSRPDLIDSALLRPGRLDKSVICNIPTESERLDILQ Drosophila_melanogaster VVNQLLTELDGVEG-LQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRIFE Arabidopsis_thaliana VVNQFLTELDGVEV-LTGVFVFAATSRPDLLDPALLRPGRLDRLLLCDFPSPPERLEILT Danio_rerio VVNQLLTQLDGVEG-LTGVYVLAASSRPDLIDPALLRPGRLDKSLYCPPPDREARLEILR Mus_musculus VVNQLLTQLDGVEG-LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILT Rattus_norvegicus VVNQLLTQLDGVEG-LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILT Homo_sapiens VVNQLLTQLDGVEG-LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILN Bos_taurus VVNQLLTQLDGVEG-LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQASRLEILN ****:**::**.* : ** ::..:** :*:* **** **:*: : * * *: *: Caenorhabditis_elegans VLTN---------KL-KPTDVDFECLAQKTDGWSGADLQLLFTNAQFYNARQIAKEEDGL Saccharomyces_cerevisiae AIVNSKDKDTGQKKFALEKNADLKLIAEKTAGFSGADLQGLCYNAYLKSVHRWLSAADQS Drosophila_melanogaster ALSS---------TLSLDECVDFDWFAGKTANYTGADIQSILTSANMAAVKEALAQFGHE Arabidopsis_thaliana VLSR---------KLLMADDIDLEPIALMTEGFSGADLQALLSDAQLAAVHEYLNREDKP Danio_rerio ALTH---------SVPLAADVDLDQIAGATELFTGADLKALLYNAQLEAIHSSLGPNLLH Mus_musculus VLSK---------SLALADDVDLQHVASVTDSFTGADLKALLYNAQLEALQGRLLPSGLP Rattus_norvegicus VLSK---------SLPLADDVDLQHVASVTESFTGADLKALLYNAQLEALQGRLLPGGLH Homo_sapiens VLSD---------SLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQ Bos_taurus VLSE---------SLPLADDVDLQHVASLTDSFTGADLKALLYGAQLEALHGRLLTGGLQ .: .. *:. .* * ::***:: : * : : Caenorhabditis_elegans EEDNVPI-DQASIE-SVFNDSIPKPKRSQVDNRIGQKVTLA------------------- Saccharomyces_cerevisiae EVVPGNDNIE----YFSINEHGRREENR--------------LRLKTLLQQDVVHET--- Drosophila_melanogaster KLAKKI-----SLKQKHLIESFQTTRPSLSASD-----------------VAKYHRTYAR Arabidopsis_thaliana ETGTTPIITDPLLKSIA-----SKTKPSVSE-----------------TEKQKLYDIYSQ Danio_rerio DLGSGSDSDV-SLSSLIFLNHSSGSDDSAGEGDAGLEHSMVLLEPSELPPEDPRHNIWRL Mus_musculus DGGSSSDSDL-SLSSMVFLNHSSGSDDSAGDGECGLEQSLLSLEMSEILPDESKFNMYRL Rattus_norvegicus DGGSSSDSDL-SLSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRL Homo_sapiens DGSSSSDSDL-SLSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRL Bos_taurus DGGSSSDSDL-SLSSMVFLNHSSGSDDSAGDGECGLEQSLVSLEMSEVLQDESKFNMYRL . Caenorhabditis_elegans ------------------------------------------------------------ Saccharomyces_cerevisiae -----KTS--------T----------SAASELT-------------------------- Drosophila_melanogaster FTNKEKTSREFVAKRATLA----------------------------------------- Arabidopsis_thaliana FLDSRKSSREAKGKRATLA----------------------------------------- Danio_rerio YFGSSFESELDNQ---SLNSQCLSGPNSTAPDLTGASVRDPSSCHAPVFMSCVQQGFQEL Mus_musculus YFGSSYESELGNGTPSDLSSHCLSAPSSVTQDLPAAPGKDPLFTQHPVFRTPSQEGCQDL Rattus_norvegicus YFGSSYESELGNGASCDLSSHCLSAPSSMTQDLPATPGKDPLFTQHPVFRTPSQEGSQDL Homo_sapiens YFGSSYESELGNGTSSDLSSQCLSAPSSMTQDLPGVPGKDQLFSQPPVLRTASQEGCQEL Bos_taurus YFGSSYESELGNGTSSDLSSQCLSAPSSMTQEFPGAPGKDQSL-RPPLFRTASQEGYQEL Caenorhabditis_elegans ------------------------------------------------------------ Saccharomyces_cerevisiae ---------------------------------------AVVTINDLLEACQETKPSIST Drosophila_melanogaster ------------------------------------------------------------ Arabidopsis_thaliana ------------------------------------------------------------ Danio_rerio SHEQSERLRAEVSTVKNSYRKTTDESSSSLVQTSPSKPGSLICQTHLTTALANTRASVSR Mus_musculus TQEQRDQLRAEISIIKGRYRSQSGED-ESLNQPGPIKTTFAISQAHLMTALAHTRPSISE Rattus_norvegicus TQEQRDQLRADISIIKGRYQSQSGED-ESLNQPGPIKTSFAISQAHLMTALAHTRPSINE Homo_sapiens TQEQRDQLRADISIIKGRYRSQSGED-ESMNQPGPIKTRLAISQSHLMTALGHTRPSISE Bos_taurus TQEQRDQLRADISIIKGRYRSQTGED-DALNPPGPSKTSLAISQSHLMTALSHTRPSISE Caenorhabditis_elegans ------------------------------------- Saccharomyces_cerevisiae SELVKLRGIYDRFQKDRNGEMPNGENSIDIGSRLSLM Drosophila_melanogaster ------------------------------------- Arabidopsis_thaliana ------------------------------------- Danio_rerio EDWKRYTELYESFGAPKERKSQSN-VLFKAGQRVTLA Mus_musculus DEGKEFAELYENFQNPKKRKNQSG-TVFRTGQKVTLA Rattus_norvegicus DEGKEFAELYENFQNPKKRKNQSG-TVFRTGQKVTLA Homo_sapiens DDWKNFAELYESFQNPKRRKNQSG-TMFRPGQKVTLA Bos_taurus DDWKTFAELYESFQNPKKRKNQSG-TVFRPGQKVTLA